Journal of cardiothoracic and vascular anesthesia
Evaluating Topical Antifibrinolytics in Cardiac Surgery: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Juan Sebastian Montoya-Beltran, Laura Ramirez-Herrera, Jorge Leandro Pinilla, Andres Herazo-Cubillos, Laura Peña-Blanco, Andres Felipe Jimenez Ordoñez
Published: 202510.1053/j.jvca.2025.10.040
Abstract
INTRODUCTION: Lysine analog antifibrinolytics (LAAF) like tranexamic acid (TXA) and aminocaproic acid (EACA) reduce intraoperative blood loss, especially in cardiac surgery where bleeding risks are high. These LAAFs inhibit fibrinolysis and have been…
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