IET systems biologyHumansBenzophenanthridinesColorectal NeoplasmsMolecular Dynamics SimulationSingle-Cell Analysis
Mechanistic Investigation of Nitidine Chloride-Mediated Anti-Colorectal Cancer Activity: Centromere-Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single-Cell Approaches.
Bin Li, Zhi-Su Liu, Ke-Jun Wu, Zong-Yu Li, Wei Zhang, Hui Li, Rong-Quan He, Di-Yuan Qin, Jing-Wen Ling, Jin-Cheng Li, Gang Chen
Published: 202610.1049/syb2.70054
Abstract
Colorectal cancer (CRC) is counted among the most widespread malignancies worldwide, characterised by elevated incidence and mortality rates. Conventional chemotherapy is frequently associated with severe toxic side effects and the development of dru…
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