Bioscience reportsMonophenol MonooxygenaseThioureaAntineoplastic AgentsHumansDrug Design
Design, synthesis, and anticancer activity of novel isocryptolepine 'aza' type acyl thiourea derivatives via combined experimental and computational approach.
Ammara Fayyaz, Syeda Abida Ejaz, Atteeque Ahmed, Pervaiz Ali Channar, Saira Afzal, Rabail Ujan, Aamer Saeed, Rifhat Bibi, Bshra A Alsfouk, Qamar Abbas, Reshma Sahito, Michael Bolte, Tuncer Hökelek
Published: 202610.1042/BSR20253519
Abstract
To identify novel tyrosinase inhibitors, a series of isocryptolepine 'aza' type acyl thiourea analogs (6a-6h) were designed and synthesized using a multistep strategy. Spectroscopic methods including FTIR, UV-vis, 1H NMR, 13C NMR, and EI-MS were util…
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