The Biochemical journal
Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26.
Scott Bailey, Iris Zheng, Brian Learn
Published: 202610.1042/BCJ20250364
Abstract
CRISPR-Cas9 systems provide adaptive immunity in prokaryotes by targeting and cleaving invading phage DNA. In response, phages have evolved anti-CRISPR (Acr) proteins to inhibit Cas9 and evade this immune response. AcrIIA26 is a type II-A anti-CRISPR…
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