The Biochemical journal
De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3.
Jessica A Buchanan, Olivia Lavidis, Nicholas Shields, Katriona Harrison, Huy T Nguyen, Richard J Payne, Toby Passioura, Megan Steain, Margaret Sunde
Published: 202610.1042/BCJ20250283
Abstract
Receptor Interacting Protein Kinase 3 (RIPK3) is a central regulator of necroptosis and a key mediator of inflammatory signaling. Its function is orchestrated through RIP Homotypic Interaction Motif (RHIM)-dependent interactions with other RHIM-conta…
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