The Biochemical journal
Serendipitous Discovery of an Allosteric Inhibitor Binding Groove in the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 1 (PYCR1).
Kaylen R Meeks, Caitlin J Mattingly, Jay C Nix, Oleksii Chuk, Mykola V Protopopov, Olga O Tarkhanova, John J Tanner
Published: 202610.1042/BCJ20250278
Abstract
Δ1-pyrroline-5-carboxylate (P5C) reductase 1 (PYCR1) catalyzes the NAD(P)H-dependent conversion of L-P5C to L-proline and is one of the most consistently upregulated metabolic enzymes in cancer cells. High PYCR1 expression is associated with adverse…
Preview only. Read the full abstract at the source