Journal of materials chemistry. BLysosomesFluorescent DyesMicrogliaHydrogen-Ion ConcentrationAmyloid beta-Peptides
Engineering fluorescent probes for tracking lysosomal pH in β-amyloid-induced microglial activation and phagocytosis.
Subrata Munan, Abir Mondal, Shraddha Tiwari, Rashmi Yadav, Niharika Pareek, Animesh Samanta
Published: 202510.1039/d5tb00968e
Abstract
Alzheimer's disease (AD) is primarily associated with the aggregation of amyloid-β (Aβ) due to insufficient clearance of Aβ peptides. This leads to deposition of fibrillar Aβ (fAβ), contributing to AD progression. Microglia, the brain's resident immu…
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