Soft matterMolecular Dynamics SimulationScatteringSmall AngleX-Ray DiffractionLipids
Combining SAXS analysis and MD simulation to determine structure and hydration of ionizable lipid hexagonal phases.
Julian Philipp, Akhil Sudarsan, Ekaterina Kostyurina, Viktoriia Meklesh, Monica Berglund, Michael Rappolt, Jan Westergren, Lennart Lindfors, Nadine Schwierz, Joachim O Rädler
Published: 202510.1039/d5sm00666j
Abstract
Cationic ionizable lipids (CILs) are fundamental components of inverse hexagonal (HII) lipid assemblies, which mediate the encapsulation and release of negatively charged mRNA through a pH-dependent mechanism. Since variations in the structure and co…
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