Organic & biomolecular chemistry
An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters.
Karin Steffen, Manuel Rangel-Grimaldo, Thomas J C Sauters, David C Rinker, Huzefa A Raja, Tyler N Graf, Adiyantara Gumilang, Olivia L Riedling, Gustavo H Goldman, Nicholas H Oberlies, Antonis Rokas
Published: 202610.1039/d5ob01965f
Abstract
Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs). Linking SMs to their BGCs is key to understanding their…
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