Organic & biomolecular chemistryAnimalsRNAMessengerNanoparticlesLung
Oxabispidine-derived ionizable lipids for effective mRNA delivery to the lungs using lipid nanoparticles.
Charles H Chen, Eric L Dane, Steven Oag, Elin Sand, Patrik Andersson, Annette Bak, Liping Zhou
Published: 202610.1039/d5ob01888a
Abstract
Lipid nanoparticles have been proven effective for mRNA delivery to the liver and in a vaccine context. There is general interest in identifying new ionizable lipids to enable safe and efficient mRNA delivery to a wider range of tissues and cells. A…
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