Organic & biomolecular chemistry
Design, synthesis, and structural analysis of an inhibitor of the gastric proton pump with a diaza-tricyclic skeleton.
Nariyoshi Umekubo, Airi Hashizume, Haruki Saito, Satoru Kato, Chisato Kanai, Chai C Gopalasingam, Christoph Gerle, Hideki Shigematsu, Atsushi Yoshimori, Kazuhiro Abe, Satoshi Yokoshima
Published: 202610.1039/d5ob01828e
Abstract
The development of potent K+-competitive acid blockers (P-CABs) as inhibitors of acid gastric secretion attracts much research attention. In this study, the structure-guided design and enantioselective synthesis of P-CABs yielded a diaza-tricyclic co…
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