Organic & biomolecular chemistry
PyBroP/base-promoted one-pot three-component sequential decarboxylative addition reaction of β-keto acids, isatylidene malononitriles and pyridine N-oxides.
Fuzhong Han, Yingdong Na, Lina Jia, Xiangping Hu
Published: 202610.1039/d5ob01772f
Abstract
A PyBroP/base-promoted three-component sequential decarboxylative nucleophilic addition protocol has been developed. Under the optimized conditions, a wide array of β-keto acids, isatylidene malononitriles and pyridine N-oxides couple efficiently to…
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