Organic & biomolecular chemistry
Beyond structure and activity: targeting class A carbapenemases with monocyclic and bicyclic boronic acids to counter antimicrobial resistance.
Kunal Dhankhar, Mousumi Hazra, Adwaita S R Nair, Alaa Eddin Alhmeidi Alkhatib, Narayan C Mishra, Saugata Hazra
Published: 202510.1039/d5ob01703c
Abstract
Bicyclic boronic acids inhibit SME-1 carbapenemase via a unique π-π stacking with His105 and covalent interaction with Ser70. Ledaborbactam shows the strongest inhibition, with the lowest ki and enhanced structural stability. X-ray crystallography an…
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