Organic & biomolecular chemistry
Elucidating the mechanism, origin of regioselectivity and substrate scope of the synthesis of structurally diverse 1,2,4-triazoles via a rare type of diazo compound reactivity.
Roman Kuznetsov, Grigory Kantin, Alexander Sapegin, Mikhail Novikov, Dmitry Dar'in
Published: 202610.1039/d5ob01650a
Abstract
The 1,2,4-triazole scaffold plays a significant role in drug development, and efficient methods for synthesizing its derivatives are in high demand. In this work, we propose a convenient approach for the synthesis of polysubstituted 1H-1,2,4-triazole…
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