A transition metal-free regioselective aza-Michael strategy for spiro-heterocycles through a formal [3 + 2]/[4 + 2] spiro-annulation of haloamines.

Given the prevalence of nitrogen-containing spiro-heterocycles in medicinal chemistry, efficient strategies for forming C-N bonds are still crucial. We describe a transition-metal-free, regioselective aza-Michael formal [3 + 2]/[4 + 2] spiro-annulati…

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