Chemoselective defluorinative amination of (trifluoromethyl)alkenes with amidines: synthesis of 6-fluoro-1,4-dihydropyrimidines.

The chemoselective defluorinative amination of (trifluoromethyl)alkenes with amidines is reported. This transition-metal-free method is operationally simple and gram-scalable, tolerates diverse useful functional groups, and gives a variety of synthet…

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