Aza-oxyallyl cation-mediated synthesis of α-sulfonyl hydroxamic acid derivatives from α-halo hydroxamates and sodium sulfinates.

α-Sulfonyl hydroxamic acid derivatives are important pharmacophores with wide-ranging applications in medicinal chemistry, particularly as enzyme inhibitors targeting metalloproteins such as MMPs, HDACs, and TACE. Here, we report a straightforward an…

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