Organic & biomolecular chemistryOligonucleotidesSulfonamidesMolecular Structure
Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages.
Romain Amador, Carine Baraguey, Guillaume Clavé, Michael Smietana
Published: 202510.1039/d5ob01382h
Abstract
We report the synthesis of (2-(N-acetylsulfamoyl)ethyl)carbamate (NAC)-linked thymidine dinucleotide via the sulfo-click reaction and its incorporation into DNA oligonucleotides. Thermal denaturation studies indicate modest destabilization at duplex…
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