Organic & biomolecular chemistryRhodiumCatalysisTyrosineMicrogliaPyrones
A rhodium-catalyzed [4 + 2] annulation strategy to synthesize pyranone-mounted tyrosines with anti-neuroinflammatory activity.
Narendra Dinkar Kharat, Sushma Naharwal, Sabyasachi Mandal, Mukul Yadav, Thimmaiah Govindaraju, Kiran Bajaj, Rajeev Sakhuja
Published: 202510.1039/d5ob01375e
Abstract
Rh(III)-catalyzed [4 + 2] annulation of C3Ar-formyl tyrosine ester with internal alkynes furnished di-substituted pyranone-mounted tyrosine-based unnatural amino acids in high yields. Selected compounds exhibited intrinsic viscosity-responsive fluore…
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