Organic & biomolecular chemistry
Heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry.
N Alfred Larsson, Taegeun Jo, Ulf Bremberg, Stefano Crespi, Luke R Odell, Daniel Fürth
Published: 202610.1039/d5ob01314c
Abstract
Dibenzocyclooctynes (DBCOs) are widely used in bioorthogonal chemistry for strain-promoted azide-alkyne cycloaddition (SPAAC), but generally lack reactivity toward inverse-electron-demand Diels-Alder cycloaddition (iEDDAC) with tetrazines. While phot…
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