NanoscaleTumor MicroenvironmentHydrogen-Ion ConcentrationHumansAnimalsProtons
Design and application of proton gradient-based pH-responsive nanomaterials in the tumor microenvironment.
Jianjun Jiang, Limin Jin, Zengkai Zhao, Pengli Gao, Mingmei Li, Xiang Zheng, Fangzhou Li
Published: 202510.1039/d5nr02990b
Abstract
The pH of the tumor microenvironment (TME) is a fundamental physicochemical parameter, and pH-responsive nanoparticles for the TME generally rely on two mechanisms: (1) protonation-induced ionization of functional groups and (2) cleavage of acid-labi…
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