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Fluorobenzylation promotes immune-activating peptides to turn cold tumors into hot tumors.
Ziqian Mu, Yudan Zhong, Yeli Fan, Junjie Yan, Lizhen Wang, Qian Xu, Donghui Pan, Yuping Xu, Chongyang Chen, Xinyu Wang, Min Yang
Published: 202510.1039/d5mh01621e
Abstract
Transforming immunologically "cold" tumors into "hot" lesions amenable to immunotherapy remains a central challenge. Here, we introduce fluorobenzylation as a sequence-dependent amplifier of peptide immunogenicity that enhances membrane interaction a…
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