Two sites, two stories: sequence-driven divergence in Cu(II) and Zn(II) binding to CusF.

Copper homeostasis is a fine balance for bacteria: essential for respiration, yet toxic in excess. While the CusCFBA efflux system exports Cu(I) from Gram-negative cells, little is known about how its periplasmic chaperone, CusF, might respond to Cu(…

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