Mechanisms and regio- and stereoselectivities in NHC-catalyzed [3+3] annulations for the synthesis of axially and centrally chiral dihydropyridinones.

Organocatalytic annulation strategies serve as an ideal approach for constructing molecules integrating both axial and central chirality, yet theoretical studies on the origin of stereoselectivity remain insufficient. In this study, the NHC-catalyzed…

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