Physical chemistry chemical physics : PCCPReceptorsLDLMolecular Dynamics SimulationAllosteric RegulationHumans
Allosteric inhibition of the PCSK9-LDLR interaction: structural insights for small molecule design.
Yong Su Baek, Siwoo Kim, Eunho Lee, Sangbae Lee
Published: 202510.1039/d5cp03269e
Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma LDL cholesterol levels through direct interaction with the LDL receptor (LDLR), making it a clinically validated target for lipid-lowering therapy. While monoclonal antibodies hav…
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