The reaction mechanism of intramolecular C-C coupling catalyzed by the non-heme deoxypodophyllotoxin synthase.

Deoxypodophyllotoxin synthase (DPS) is a non-heme dioxygenase from Sinopodophyllum hexandrum that catalyzes the intramolecular C-C coupling reaction between the aromatic ring and the methylene group in the synthesis of the antitumor natural product p…

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