Physical chemistry chemical physics : PCCPMolecular Dynamics SimulationProteolysisHumansCell Cycle ProteinsUbiquitin-Protein Ligases
Characterizing the conformational ensemble of PROTAC degraders in solutions via atomistic simulations.
Shikshya Bhusal, Omar Valsson
Published: 202510.1039/d5cp02530c
Abstract
Targeted protein degradation has emerged as a promising strategy for developing novel therapeutics, particularly for "undruggable" disease-related proteins. One approach is the use of PROteolysis TArgeting Chimeras (PROTACs) degraders, which induce t…
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