Carbene-catalyzed [2+2] cycloaddition of chloroaldehydes and isatin-derived ketimines for enantioselective synthesis of spirocyclic β-lactams.

An N-heterocyclic carbene-catalyzed asymmetric [2+2] cycloaddition reaction of α-chloroaldehydes with isatin-derived ketimines is developed. This protocol tolerates a wide range of substrates featuring various substitution patterns, and under mild, o…

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