Enzymatic trifluoropropylation by a trifluoropropyl S-adenosylmethionine analogue.

The trifluoropropyl group is valuable in medicinal chemistry for enhancing drug stability and bioavailability. Selective trifluoropropylation is a challenge. Here, we have developed an enzymatic approach using a trifluoropropyl S-adenosylmethionine a…

Preview only. Read the full abstract at the source