Chemical communications (Cambridge, England)RNAMolecular Dynamics SimulationDNANucleic Acid ConformationDNA Replication
A-type helicity controls efficient nonenzymatic template copying of nucleic acids.
Barbara K Lech, Petr Jurečka, Marie Zgarbová, Rafał Szabla
Published: 202610.1039/d5cc05343a
Abstract
We performed classical molecular dynamics simulations for DNA self-replication on an RNA template with phosphoroimidazole activation. We demonstrate that the RNA template imposes A-type helicity on the hybrid DNA/RNA helix, as opposed to the B-type h…
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