Controlled condensation reaction of an immobilized bis(hydroxymethyl)arene and mobile phenols in metal-organic frameworks.

We report a Sc(OTf)3-catalyzed Friedel-Crafts alkylation between immobilized bis(hydroxymethyl)arenes in MOFs and mobile electron-rich arenes. Reactivity is controlled by guest concentration: high concentrations yield mono-substitution (post-syntheti…

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