Rh(III)-catalyzed C-H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif.

The β-amino α-fluorocarbonyl motif is a privileged scaffold in medicinal chemistry, yet its efficient synthesis from readily available precursors remains challenging. Herein, we report a Rh(III)-catalyzed cascade reaction that constructs 3,4-dihydroi…

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