Analytical methods : advancing methods and applicationsHumansCRISPR-Cas SystemsCirculating Tumor DNALimit of DetectionEndodeoxyribonucleases
Rapid and sensitive detection of circulating tumor DNA via a CRISPR/Cas12a-based catalytic hairpin assembly.
Songbai Tian, Lingzi Yao, Feng Gong, Ying Li, Yujie Zhao, Yixia Yang
Published: 202610.1039/d5ay01624j
Abstract
Cancer is one of the major diseases that endanger the human health. Circulating tumor DNA (ctDNA) is an ideal biomarker for the real-time monitoring of cancer. In the present work, a rapid and sensitive assay coupled with CRISPR/Cas12a and CHA (Cas12…
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