Analytical methods : advancing methods and applicationsAnimalsTandem Mass SpectrometryRatsPiperidinesTissue Distribution
Development and validation of a novel LC-MS/MS method for simultaneous quantification of alvocidib and its glucuronide: application to pharmacokinetic and tissue distribution study in rats.
Eric Asare, Ting Du, Yuan Chen, Shalom Emmanuel, Huan Xie, Dong Liang, Song Gao
Published: 202510.1039/d5ay01143d
Abstract
Alvocidib, an approved drug for the treatment of acute myeloid leukemia, undergoes glucuronidation metabolism. The purpose of this study is to develop a robust and sensitive LC-MS/MS method to simultaneously quantify alvocidib and its metabolite, alv…
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