EMBO molecular medicine
A viral glycoprotein targets IgG+ memory B cells to mediate humoral immune evasion.
Precious Cramer, Stefan F H Neys, Manuela Fiedler, Raquel Lorenzetti, Henrike Reinhard, Iga Janowska, Julian Staniek, Ann-Katrin Kohl, Petra Hadlova, Magdalena Huber, Bodo Plachter, Clarissa Read, Valeria Falcone, Jens von Einem, Katja Hoffmann
Published: 202610.1038/s44321-026-00372-1
Abstract
Virus infections elicit long-term IgG antibody and memory responses. Human cytomegalovirus (HCMV) is widespread in humans and disseminates despite the presence of virus-specific antibodies. Here, we report that the HCMV Fcγ-binding glycoprotein 34 mo…
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