EMBO molecular medicine
Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins.
Bide Tong, Xiaoguang Zhang, Dingchao Zhu, Yulei Wang, Junyu Wei, Zixuan Ou, Huaizhen Liang, Hanpeng Xu, Zhengdong Zhang, Jie Lei, Xingyu Zhou, Di Wu, Yu Song, Kun Wang, Xiaobo Feng
Published: 202610.1038/s44321-025-00371-8
Abstract
Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems. Extracellular vesicles (EVs) have shown potential to act as next-generation TPD platform…
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