EMBO molecular medicine
Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule.
Debajyoti Das, Amanda Wyatt, Sarath Sivaprasad, Vanessa Wahl, Sen Qiao, Fabien Ectors, Zulfiah M Moosa, Claire L Newton, Mario Fritz, Robert P Millar, Ulrich Boehm
Published: 202610.1038/s44321-025-00369-2
Abstract
G protein-coupled receptors (GPCRs) carry out the majority of cellular transmembrane signaling. Many pathologies have underlying GPCR mutations, most of which cause misfolding and GPCR cell surface trafficking failure. Large libraries of existing sma…
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