EMBO molecular medicine
TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome.
Juan M Lozano-Gil, Lola Rodríguez-Ruiz, Manuel Palacios, Jorge Peral, Susana Navarro, José L Fuster, Cristina Beléndez, Andrés Jérez, Laura Murillo-Sanjuán, Cristina Díaz-de-Heredia, Guzmán López-de-Hontanar, Josune Zubicaray, Julián Sevilla, Francisca Ferrer-Marín, María P Sepulcre
Published: 202610.1038/s44321-025-00368-3
Abstract
Diamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activation of the NLRP1 inflammasome affects erythroid diff…
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