EMBO molecular medicine
The critical role of the proto-oncogene c-Kit in TSC renal cystogenesis.
Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Wenzheng Zhang, Jane J Yu, Nathan A Zaidman, Manoocher Soleimani
Published: 202510.1038/s44321-025-00360-x
Abstract
The epithelium of kidney cysts in mouse Tuberous Sclerosis complex (TSC) models and TSC patients is composed of proliferating A-intercalated cells. The ablation of the Foxi1 gene abolished renal cystogenesis in principal cell-specific Tsc1 knockout (…
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