Molecular systems biology
Essentiality and dynamic expression of the human tRNA pool during viral infection.
Noa Aharon-Hefetz, Michal Schwartz, Einav Aharon, Noam Stern-Ginossar, Orna Dahan, Yitzhak Pilpel
Published: 202610.1038/s44320-025-00181-7
Abstract
Human viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) and SARS-CoV-2. HCMV-induced alterat…
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