EMBO reports
IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella.
Maxence Cornut, Sophia Djebali, Elena Rondeau, Sarah Dayet, Théo Fayolle, Julie Haagen, Lucie Fallone, Noémi Rousseaux, Emmanuelle Caspar, Mélissa Marcotte, Amandine Martin, Elise Courteboeuf, Maëlan Deschamps-Biboulet, Marie Teixeira, Jacqueline Marvel
Published: 202610.1038/s44319-026-00698-4
Abstract
IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO mice and demonstrate that they are equally suscept…
Preview only. Read the full abstract at the source