EMBO reports
Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance.
Gabriela Zurawska, Zuzanna Sas, Aneta Jończy, Raghunandan Mahadeva, Patryk Slusarczyk, Marta Chwałek, Daniel Seehofer, Georg Damm, Rafał Mazgaj, Marcin Skórzyński, Maria Kulecka, Izabela Rumieńczyk, Morgane Moulin, Kamil Jastrzębski, Kevin Waldron
Published: 202610.1038/s44319-025-00673-5
Abstract
Mild rupture of aged erythrocytes occurs in the spleen, resulting in hemoglobin (Hb) release, whereas pathological hemolysis characterizes several diseases. Hb detoxification is attributed to macrophages, but other routes of Hb clearance remain elusi…
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