The EMBO journal
A fibroblast-like endothelial cell state promotes atherosclerosis via C/EBPβ-activated TGF-β signaling.
Linge Fan, Yingyi Zhu, Yi Li, Zixin Ji, Kefan Ma, Ying Zhang, Leiting Wei, Junbo Chen, Yuanqing Jiang, Dongwu Lai, Lingfeng Qin, Guosheng Fu, Michael Simons, Liang Xu, Luyang Yu
Published: 202610.1038/s44318-025-00684-x
Abstract
Endothelial cell (EC) dysfunction is a critical driver of chronic vascular inflammation and atherosclerosis. However, the molecular details of EC state dynamics during vascular disease progression remain ill-defined. Here, we used in-depth single-cel…
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