The EMBO journal
E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.
Luyi Jiang, Jiangfen Tang, Ya-Fen Zhang, Wen-Xuan Zou, Gang Deng, Na Tian, Xiaolu Zhao, Lei Han, Kai Liu, Bao-Liang Song, Jie Luo
Published: 202510.1038/s44318-025-00654-3
Abstract
Localization of lysosomes influences their properties, e.g., perinuclear lysosomes are more acidic but less mobile compared with the peripheral ones. Furthermore, the endoplasmic reticulum (ER) can actively regulate the dynamics and functions of lyso…
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