The EMBO journal
A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.
Xinyu Xiang, Anni Gao, Dominik Handler, Francisco Falcon, Diego Rodriguez-Terrones, Sergej Nowoshilow, Wanlu Liu, Elly M Tanaka, Dónal O'Carroll
Published: 202510.1038/s44318-025-00631-w
Abstract
The piRNA pathway protects animal germlines from active transposons. Mammals employ a cytoplasmic pathway to destroy transposon transcripts during germline reprogramming. This post-transcriptional mechanism is ancient and found throughout the animal…
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