Nature cardiovascular researchHumansReceptorsAryl HydrocarbonCell ProliferationAnimals
A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells.
Yang Lin, Fuqiang Geng, Jae-Hung Shieh, Lisa K Torres, Musia Sominskaia, Meng Gao, Matthew Wingo, Kevin Chen, Samir Rustam, Raul Chavez, Renat Shaykhiev, Aleksandra Kopacz, Bradley Pearson, David Redmond, Ryan Schreiner
Published: 202510.1038/s44161-025-00716-z
Abstract
Tissue-specific endothelial cells (ECs) regulate metabolism, inflammation, coagulation, organ development and regeneration. However, therapeutic application of EC transplantation requires scalable expansion of engraftable ECs that sustain their angio…
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