Communications medicine
Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer.
Jennifer A Heritz, Sarah J Backe, Angela Pacherille, Sara J Cayaban, Michael F Basin, Britannia Smith, Rebecca A Sager, Michael Daneshvar, Dawn E Post, Mark R Woodford, Dimitra Bourboulia, John D Chisholm, Mehdi Mollapour, Gennady Bratslavsky
Published: 202610.1038/s43856-025-01356-x
Abstract
BACKGROUND: The transcription factor Hypoxia-Inducible Factor 2α (HIF2α) plays a crucial role in cancer cell adaptation to hypoxic conditions, particularly in clear cell renal cell carcinoma, promoting tumor growth and angiogenesis. Targeting HIF2α t…
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