Nature agingAnimalsHematopoietic Stem CellsInflammationMiceAging
Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging.
Tongyao Shang, Li Zhao, Shibo Ying, Lida Su, Yue Yang, Jiadong Liu, Yingying Wang, Jipeng Xue, Cheng Cheng, Yixin Wu, Shiyao Chen, Hongmei Dong, Xuequn Chen, Hailin Ma, Qi Zhang
Published: 202610.1038/s43587-025-01039-1
Abstract
Hematopoietic stem cells (HSCs) reside in the bone marrow in a quiescent state, but can be mobilized into the blood in response to inflammation, cytokine stimulation, nervous activity or hypoxia. Chronic inflammation, a hallmark of aging, accelerates…
Preview only. Read the full abstract at the source