Nature cancer
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency.
Philip Bucher, Nadine Brückner, Jule Kortendieck, Melanie Grimm, Jan T Schleicher, Karlotta Bartels, Steffen Hardy, Martina Rausch, Hannah Wurzer, Meike Thiemann, Celina May, Mara Mitstorfer, Dennis Letzgus, Julia Quach, Carolin Schneider
Published: 202610.1038/s43018-025-01099-7
Abstract
Insufficient functional T cell persistence impedes therapeutic success of chimeric antigen receptor (CAR) therapies. Here we performed a CAR-adapted base-editing screen of PIK3CD, a key regulator of T cell function, metabolism and fate. We identified…
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