Nature cancer
Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.
Kadriye Nehir Cosgun, Huda Jumaa, Mark E Robinson, Zhangliang Cheng, Salim Oulghazi, Kohei Kume, David Fonseca Arce, Nikol Agadzhanian, Klaus M Kistner, Etienne Leveille, Elsa Drivet, Fang Yu, Zhijian Qian, Joo Y Song, Wing-Chung Chan
Published: 202610.1038/s43018-025-01093-z
Abstract
As part of canonical Wnt signaling, T cell factor (TCF)-β-catenin complexes promote MYC-dependent proliferation. Lesions of the β-catenin protein degradation machinery are common oncogenic drivers. Here, we show that B cell acute lymphoblastic leukem…
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